Wheelchair safety is an important concern, especially for new wheelchair users. Wheelchair users should be aware of how the center of gravity of the wheelchair changes when they perform certain activities such as picking up objects off the floor.

Wheelchairs can have mechanical failures or not work at their optimum level. There should be routine inspections of the mechanics of wheelchairs, especially of the brakes which can become worn. Necessary repairs should be addressed in a timely manner.

Wheelchair users should avoid reaching forward to pick up objects on the floor. This could cause the wheelchair to tip forward. A safer way is to position the wheelchair beside the item and reach over the side of the wheelchair to pick up the item.

Stretching and reaching backwards and shifting the body to reach backwards are not safe since they could cause the wheelchair to tip backwards. It would be much safer for the wheelchair user to reposition the wheelchair so that the item is within the natural extension of the arm.

When using steps or crossing over curbs, the only safe way is for the wheelchair users to have the assistance of an attendant. The wheelchair user should use ramps or ways to avoid these obstacles if the wheelchair user is alone.

Wet surfaces and holes can often be avoided if the wheelchair user is paying attention. These are sometimes referred to as surface hazards. If the problematic area cannot be avoided, it should be negotiated carefully.

Sloped surfaces take more strength to control and maneuver the wheelchair than flat surfaces. Wheelchair users should know their ability to use ramps and other inclining and declining surfaces before using them on their own.

Safety features are available for specific needs of wheelchair users. A belt with an alarm can alert attendants if a wheelchair user who is not stable on their feet tries to stand up.